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KMID : 0352719990230040235
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Journal of Ginseng Research
1999 Volume.23 No. 4 p.235 ~ p.238
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Ginsenoside Rg3 Increases the ATP-sensitive K+ Channel Activity in the Smooth Muscle of the Rabbit Coronary Artery
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정인덕/Induk Chung
Jeong Sun Lee
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Abstract
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ATP-sensitive K+ channels (KATP) are expressed in vascular smooth muscle cells, skeletal muscle cells, pancreatic β cells, neurons and epithelial cells. KATP contributes to regulate membrane potential to control vascular tone, to protect myocardial ischemia, and to regulate insulin secretion in pancreatic β cells. We previously demonstrated that ginseng saponins and ginsenoside Rg3 activated maxi Ca2+?activatedK+ channel, and this might cause vasodilation. Because KATP plays an important roles to regulate the resting membrane potential in vascular smooth muscle cells, we investigated whether ginsenoside Rg3 produces vasodilation by activating KATP We showed in this study that KATP is expressed in rabbit coronary artery smooth muscle cells. KATP was inwardly rectifying and was inhibited by intemal application of ATP. Micromolar minoxidil activated, but glyburide inhibited the activity of KATP Ginsenoside Rg3 relieved inactivaiton of whole-cell KATP current without affecting the peak amplitude of KATP currents presumably due to more opening of the channels.
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